Brain Imaging in Substance Abuse
Language: en
Pages: 425
Authors: Marc J. Kaufman
Categories: Medical
Type: BOOK - Published: 2000-09-29 - Publisher: Springer Science & Business Media

The last two decades have seen prodigious growth in the application of brain imaging methods to questions of substance abuse and addiction. Despite considerable advances in our understanding of the central effects of drugs provided by preclinical data, relatively little direct evidence was known of how substances of abuse affect the brain and other eNS processes in humans. Brain imaging techniques have allowed access to the human brain and enabled the asking of questions never before imagined. The positron emission tomography (PET) data ofVolkow and her colleagues in the late 1980s, showing the uptake and time course of cocaine's binding in the human brain, revealed for the first time the distinct sites of action of this drug. This work was extremely important because it showed clearly, through imaging a drug in the brain of a living human, that the time course of its action paralleled the behavioral state of "high. " This study marked a turning point in our understanding of drug-brain-behav ior interactions in humans. Many more investigations of drug effects on the structure and function of the human brain were soon to follow, leading to much better insights into brain systems. Brain imaging allowed for the direct assessment of structural and functional anatomy, biology, and chemistry in substance abusers.
Brain Imaging in Substance Abuse. Forensic Science and Medicine
Language: en
Pages:
Authors: Marc J. Kaufman
Categories: Medical
Type: BOOK - Published: 2001 - Publisher:

With the growing availability and decreasing cost of brain imaging technologies, it has become possible for researchers, physicians, forensics experts, and legal professionals to study brain changes in humans associated with substance abuse. In Brain Imaging in Substance Abuse: Research, Clinical, and Forensic Applications, highly experienced clinical researchers from diverse fields describe the use of electroencephalography, emission tomography, and magnetic resonance imaging to study the neural effects of substance abuse. The authors detail the effects of drugs, including alcohol, benzodiazepines, marijuana, opiates, cocaine, amphetamines, hallucinogens, and solvents on brain electrical activity, metabolism, hemodynamics, receptor and neurotransmitter levels, neurochemistry, and structure. The striking findings they report emerge from more than 1350 articles in some 320 journals, and are organized by method, abused substance and drug use state. The book examines the most commonly used neuropsychological tests and highlights associations between neuroimaging findings and behavior. Comprehensive and readily accessible, Brain Imaging in Substance Abuse: Research, Clinical, and Forensic Applications offers psychiatrists, radiologists, neurologists, pharmacologists, physiologists, psychologists, substance abuse specialists, and legal professionals a broad yet thoroughly integrated understanding of the methods and results obtained with clinical neuroimaging studies of substance abuse today.
Brain Imaging in Behavioral Medicine and Clinical Neuroscience
Language: en
Pages: 404
Authors: Ronald A. Cohen, Lawrence H. Sweet
Categories: Psychology
Type: BOOK - Published: 2010-12-09 - Publisher: Springer Science & Business Media

Rapid developments in brain neuroimaging methods have occurred over the past decade. These advances have revolutionized cognitive and behavioral neuroscience, and are likely to have major influence on clinical psychological, psychiatric, and neurological practice over the coming years. There are a number of excellent books that focus on specific neuroimaging methods, such as fMRI. Furthermore, cognitive and neuroscience texts have increasingly incorporated functional brain neuroimaging. Yet, there are few books to date that consider and review emerging research in the application of brain neuroimaging methods for the study and assessment of behavioral and cognitive disorders. This book provides a broad coverage of current research trends in the clinical application of brain neuroimaging methods in the context of behavioral medicine, neuropsychology, and related areas of medical psychology. It uniquely integrates current neuroimaging methods and studies with current behavioral medicine research, and presents knowledge derived from recent developments in the fields of functional and structural brain imaging. By integrating information from experimental behavioral medicine with clinical insights, this book will serve as a source book for neuropsychologists, psychologists, neurologists, psychiatrists, and other professionals in both clinical practice and academic context. This integration results in the reader having a greater understanding of how the brain controls behavior, the disturbances of behavior that may occur with different disorders, and what clinicians should consider when assessing or working with patients with behavioral problems.
Brain Imaging in Behavioral Neuroscience
Language: en
Pages: 394
Authors: Cameron S. Carter, Jeffrey W. Dalley
Categories: Medical
Type: BOOK - Published: 2011-11-04 - Publisher: Springer Science & Business Media

This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer’s disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.
Neuroimaging in Addiction
Language: en
Pages: 352
Authors: Bryon Adinoff, Elliot A. Stein
Categories: Medical
Type: BOOK - Published: 2011-11-02 - Publisher: John Wiley & Sons

Neuroimaging in Addiction presents an up-to-date, comprehensive review of the functional and structural imaging human studies that have greatly advanced our understanding of this complex disorder. Approaching addiction from a conceptual rather than a substance-specific perspective, this book integrates broad neuropsychological constructs that consider addiction as a neuroplastic process with genetic, developmental, and substance-induced contributions. The internationally recognized contributors to this volume are leaders in clinical imaging with expertise that spans the addiction spectrum. Following a general introduction, an overview of neural circuitry and modern non-invasive imaging techniques provides the framework for subsequent chapters on reward salience, craving, stress, impulsivity and cognition. Additional topics include the use of neuroimaging for the assessment of acute drug effects, drug-induced neurotoxicity, non-substance addictive behaviors, and the application of imaging genetics to identify unique intermediate phenotypes. The book concludes with an exploration of the future promise for functional imaging as guide to the diagnosis and treatment of addictive disorders. Scientists and clinicians will find the material in this volume invaluable in their work towards understanding the addicted brain, with the overall goal of improved prevention and treatment outcomes for patients. Features a Foreword by Edythe London, Director of the Center for Addictive Behaviors, University of California at Los Angeles.